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Among the eight tested compounds, DJX-A-KA and DJX-A-KG which incorporate the previously reported 2 H -azirine warhead known to recruit NEDD4 exhibited significant KRAS G12C degradation

An overgrowth of bacteria in the small intestine can disrupt the natural balance of histamine-processing enzymes

The top 7 hubs (highest degree) were in descending order of importance: TNF (degree = 63), IL-6 (61), IL-1 (58), ALB (54), TLR4 (47), IL-10 (47), and CTNNB1 (46)

doi: 10.1159/000048668

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